In a newly published paper, Chen examines the “information-efficiency” of different scanning patterns for 3D single-particle tracking. Using Fisher information as a guide, Chen demonstrates that localization precision can be improved nearly two-fold by selectively sampling high-information off-center locations. Check out the full paper here:

https://doi.org/10.3390/e23050498

This paper is included in the special issue on Recent Advances in Single-Particle Tracking: Experiment and Analysis in Entropy.

Kevin presents at SPIE Photonics West on Xiaoqi’s intracellular solvation work and Shangguo and Jack’s real-time 3D single-molecule tracking. Links below!

Uncovering solvation heterogeneity in live cells via hyperspectral stimulated Raman scattering microscopy

Untethering single molecule spectroscopy with 3D-SMART

Xiaoqi successfully defended her thesis entitled “Uncovering the ‘Shape’ of Intracellular Water by Hyperspectral Stimulated Raman Scattering Microscopy”. Congratulations to Dr. Lang, the first PhD from our group! Her work established a new line of inquiry in the lab that will persist for years to come. We wish Xiaoqi all the best as she moves on to her postdoctoral work with Prof. Wei Min at Columbia University!

Courtney unveiled her latest microscopy method (3D-TrIm), which aims to capture the early events in viral infection by “locking on” to individual viral particles. See her BPS 2021 presentation on the Presentations page or at the link below:

Jonathan Aguilar joins the single-virus tracking / 3D-TrIm team. Jonathan follows a proud tradition of exceptional Duke undergrads diving into the wonderful world of active microscopy. Welcome aboard, Jonathan!

Curious about what we do here at the Welsher Lab? Head over to the Research Overview page to find a brief video on the group’s active microscopy projects! You can also find it on YouTube:

https://youtu.be/8aaP1Kmndow

A warm Welsher Lab welcome to 1st-year graduate student Yuxin Lin! Yuxin is still abroad, but we hope to have him here in Durham for the start of the Spring semester. Welcome, Yuxin!

Head on over to the new “Presentations” page to see a recording of Kevin presenting Xiaoqi’s intracellular solvation work using hsSRS!

Presentations

We will be presenting in two symposia at the virtual ACS meeting this week. Both are free to attend!

First is “Progress in 3D-SMART” on Tuesday 8/18 at 12PM EDT

Zoom link: http://phys-acs.org/sf2020/zoom_links.html (Symposium #3)

Schedule: Schedule for ACS Symposium on Single-Molecule Microscopy

Second is “Probing Solvation in Live Cells with SRS Microscopy” on Wednesday 8/19 at 1 PM EDT:

Schedule and Zoom Link: https://calhoun.utk.edu/ACS2020.html or http://phys-acs.org/sf2020/zoom_links.html (Symposium #7)

Come hear the latest and greatest!